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Zen (Hypoallergenic) contains GABA, which is the major inhibitory neurotransmitter in the brain and is active at 20% of CNS synapses.  There is evidence that anxiety and panic disorders are associated with excessive neuronal activity consequent to a decrease in GABA's function as an inhibitory mediator. The adverse psychological signs associated with premenstrual syndrome may be due to a dysregulated sensitivity of GABA receptors.  Zen Product Page - Allergy Research  
  

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